海人酸诱导的纹状体神经毒性：一项组织荧光研究。
Kainic acid-induced neurotoxicity in the striatum: a histofluorescent study.
作者信息
Gottesfeld Z, Jacobowitz D M
出版信息
Brain Res. 1979 Jun 29;169(3):513-8. doi: 10.1016/0006-8993(79)90400-1.
Histochemical observation of catecholamine terminals in the striatum following kainic acid injections revealed a 'sphere of influence' which contained an increased intensity of dopamine fluorescence as well as non-specific tissue destruction at the injection site. The area of involvement was approximately 50% of the striatum and varied somewhat at any one dose range depending upon the site of injection. It is suggested that destruction of regulatory neuronal systems (cholinergic, GABAergic, peptidergic, etc.) results in a net increase of dopamine in the sphere of kainic acid influence.
对注射海藻酸后纹状体中儿茶酚胺终末的组织化学观察显示出一个“影响范围”，该范围内多巴胺荧光强度增加，同时注射部位存在非特异性组织破坏。受累区域约占纹状体的50%，在任何一个剂量范围内，其大小会因注射部位而有所不同。有人认为，调节性神经元系统（胆碱能、γ-氨基丁酸能、肽能等）的破坏导致在海藻酸影响范围内多巴胺净增加。
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