Mitta M, Ohnogi H, Mizutani S, Sakiyama F, Kato I, Tsunasawa S
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Otsu, Japan.
DNA Res. 1996 Feb 29;3(1):31-5. doi: 10.1093/dnares/3.1.31.
The nucleotide sequence of a cDNA coding for the human acylamino acid-releasing enzyme (AARE, also known as acylpeptide hydrolase) [EC 3.4.19.1] subunit has been determined. The amino acid sequence of human AARE subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (91.5%) with both the corresponding proteins from the pig and the rat. The AARE cDNA shows 99.2% identity with a 3.3 kb cDNA transcribed from a locus (DNF15S2) on the short arm of human chromosome 3, whose deletion is associated with small cell lung cancer, taking into consideration that the sequence of the 3.3-kb cDNA previously reported was caused by misreading.
已确定编码人酰基氨基酸释放酶（AARE，也称为酰基肽水解酶）[EC 3.4.19.1]亚基的cDNA的核苷酸序列。从其cDNA核苷酸序列推导的人AARE亚基的氨基酸序列与猪和大鼠的相应蛋白质具有高度同一性（91.5%）。考虑到先前报道的3.3 kb cDNA的序列是由误读导致的，AARE cDNA与从人3号染色体短臂上的一个位点（DNF15S2）转录的3.3 kb cDNA显示出99.2%的同一性，该位点的缺失与小细胞肺癌相关。
