Melander A, Danielson K, Scherstén B, Thulin T, Wåhlin E
Clin Pharmacol Ther. 1977 Jul;22(1):100-3. doi: 10.1002/cpt1977221100.
The influence of food intake on the bioavailability of canrenone, the major and active metabolite of spironolactone, was explored in 8 healthy male volunteers. Spironolactone was administered as a single oral dose of 100 mg, both in the fasting state and together with a standardized breakfast. Numerous venous blood samples were taken from 30 min to 96 hr after ingestion of the drug, and the plasma concentrations of canrenone were determined by spectrofluorometry. The results indicate that more canrenone enters the general circulation when spironolactone in ingested together with a meal.
在8名健康男性志愿者中研究了食物摄入对螺内酯主要活性代谢产物坎利酮生物利用度的影响。在禁食状态下以及与标准早餐一起服用时，螺内酯均以100 mg的单次口服剂量给药。在摄入药物后30分钟至96小时采集了大量静脉血样，并用荧光分光光度法测定血浆中坎利酮的浓度。结果表明，当螺内酯与食物一起摄入时，有更多的坎利酮进入体循环。
