Melander A, Danielson K, Hanson A, Rudell B, Scherstén B, Thulin T, Wåhlin E
Clin Pharmacol Ther. 1977 Jul;22(1):104-7. doi: 10.1002/cpt1977221104.
The influence of food on the bioavailability of hydralazine in noncoated and coated tablets was examined in 5 healthy males. Each subject received an oral 50-mg dose on four different occasions: two 25-mg noncoated tablets with and without food and one 50-mg coated tablet with and without food. The meal was a standardized breakfast of 440 calories. Venous blood samples were obtained during a 6-hr period, and the plasma concentrations of unmetabolized hydralazine were assessed by a selective and sensitive gas chromatographic method. The results indicate that food enhances the bioavailability of hydralazine 2- to 3-fold both when noncoated and coated tablets are used.
在5名健康男性中研究了食物对非包衣片和包衣片中肼屈嗪生物利用度的影响。每位受试者在四个不同时间接受口服50毫克剂量：两片25毫克非包衣片，一次与食物同服，一次不与食物同服，以及一片50毫克包衣片，一次与食物同服，一次不与食物同服。餐食为一份440卡路里的标准化早餐。在6小时内采集静脉血样，并用选择性灵敏气相色谱法评估未代谢肼屈嗪的血浆浓度。结果表明，无论使用非包衣片还是包衣片，食物均可使肼屈嗪的生物利用度提高2至3倍。
