Leys A M, Leys M J, Hooymans J M, Craandijk A, Malenfant M, van Germeersch D, Priem H, de Laey J J
Department of Ophthalmology, Universitaire Ziekenhuizen, Leuven, Belgium.
Retina. 1996;16(2):89-96. doi: 10.1097/00006982-199616020-00001.
BACKGROUND/PURPOSE: Abnormal retinal vessels may develop in a region of myelinated nerve fibers, and these vessels may cause vitreous hemorrhages.
The clinical histories of seven patients with retinovascular abnormalities in a patch of myelinated nerve fibers are presented. None of the reported patients had other evidence of systemic disease. The cases were traced by a multicentric retrospective study.
Retinal vascular abnormalities ranged from mild telangiectasis to frank neovascularization, with or without obstruction of the capillary network and signs of branch artery and vein occlusion. Age at diagnosis ranged from 15 to 68 years. Vitreous hemorrhages occurred in the four youngest patients and occurred at 15, 27, 27, and 43 years of age. Laser photocoagulation was applied in three patients and vitrectomy was performed in one.
The authors' findings suggest that the abnormal structure of the myelinated nerve fibers and the thickened nerve fiber layer of the affected portions of retina may play a role in the onset of retinal vascular abnormalities and eventually cause telangiectasis, branch artery and vein occlusion, neovascularization, and vitreous hemorrhages. This suggestion is based on the absence of other causes of neovascularization or vitreous hemorrhage in all seven patients, and on the relatively young age of four of the patients with this association.
背景/目的：在有髓神经纤维区域可能会出现异常视网膜血管，这些血管可能导致玻璃体积血。
介绍了7例在一片有髓神经纤维区域出现视网膜血管异常患者的临床病史。所有报告的患者均无其他全身性疾病证据。通过多中心回顾性研究追踪这些病例。
视网膜血管异常范围从轻度毛细血管扩张到明显的新生血管形成，伴有或不伴有毛细血管网络阻塞以及分支动静脉阻塞迹象。诊断时年龄从15岁到68岁不等。4名最年轻的患者发生了玻璃体积血，年龄分别为15岁、27岁、27岁和43岁。3例患者接受了激光光凝治疗，1例患者进行了玻璃体切除术。
作者的研究结果表明，有髓神经纤维的异常结构以及视网膜受累部分增厚的神经纤维层可能在视网膜血管异常的发生中起作用，并最终导致毛细血管扩张、分支动静脉阻塞、新生血管形成和玻璃体积血。这一观点基于所有7例患者均无其他新生血管形成或玻璃体积血的病因，以及4例出现这种关联的患者相对年轻。
