Yamamoto M, Hibi H, Miyake K, Kitagawa T, Asada Y, Suganuma N, Tomoda Y
Department of Urology, Nagoya University School of Medicine.
Nagoya J Med Sci. 1996 Mar;59(1-2):31-5.
To investigate whether the variable length of the epididymis in men with congenital bilateral absence of the vas deferens (CBAVD) might have a correlation with fertilization and pregnancy rates in in vitro fertilization (IVF) treatment, we conducted a retrospective study involving a total of 60 CBAVD patients. All patients in this study had epididymal micropuncture in conjunction with perivascular nerve stimulation as part of the IVF program at the Nagoya University Hospital Reproduction Center. The patients were classified into 3 groups: group I consisted of patients having only a proximal portion of the caput epididymidis with a length of between 0.5 and 1.9 cm, group II consisted of patients with the caput and a portion of the corpus epididymidis with a length of between 2.0 and 4.0 cm, and group III consisted of patients with the caput, corpus and cauda of the epididymis measuring more than 4.0 cm. There were no differences in the sperm count, progression and normal morphology among the 3 groups; however, the motility was progressively higher in patients with a longer epididymis (12% in group 1, 18% in group II and 31% in group III). It was evident that group III showed the highest fertilization and pregnancy rate per patient (23% and 28%, respectively) among the 3 groups. This study shows that epididymal sperm from CBAVD patients with a longer epididymis have a higher IVF rate than CBAVD patients with a shorter epididymis.
为了研究先天性双侧输精管缺如（CBAVD）男性患者附睾长度的变化是否与体外受精（IVF）治疗中的受精率和妊娠率相关，我们进行了一项回顾性研究，共纳入60例CBAVD患者。本研究中的所有患者在名古屋大学医院生殖中心接受IVF治疗时，均进行了附睾微穿刺联合血管周围神经刺激。患者被分为3组：I组由仅具有长度在0.5至1.9厘米之间的附睾头近端部分的患者组成，II组由具有附睾头和部分附睾体且长度在2.0至4.0厘米之间的患者组成，III组由附睾头、附睾体和附睾尾长度超过4.0厘米的患者组成。3组之间的精子计数、活力和正常形态没有差异；然而，附睾较长的患者精子活力逐渐升高（I组为12%，II组为18%，III组为31%）。显然，III组患者的每位患者受精率和妊娠率在3组中最高（分别为23%和28%）。这项研究表明，附睾较长的CBAVD患者的附睾精子比附睾较短的CBAVD患者具有更高的IVF率。
