Shastri N
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
Curr Opin Immunol. 1996 Apr;8(2):271-7. doi: 10.1016/s0952-7915(96)80067-7.
The antigen receptors of T cells are engaged by unique peptides displayed by MHC molecules on the antigen-presenting cell surface. These rare peptides can now be distinguished among the thousands normally bound to MHC molecules. Knowledge of the antigenic peptides and their donor proteins is suggesting potential targets for immunotherapy and providing insights into the cellular mechanisms that generate the peptide-MHC complexes.
T细胞的抗原受体与抗原呈递细胞表面MHC分子所展示的独特肽段相结合。现在，这些罕见的肽段能够在通常与MHC分子结合的数千种肽段中被区分出来。对抗原肽及其供体蛋白的了解正在提示免疫治疗的潜在靶点，并为生成肽-MHC复合物的细胞机制提供见解。
