克罗恩病患者的死亡率
Mortality in patients with Crohn's disease.
作者信息
Cottone M, Magliocco A, Rosselli M, Pinzone F, Oliva L, Orlando A, Aiala M R, Cipolla C, Pagliaro L
机构信息
Istituto di Clinica Medica R, Ospedale V. Cervello, Palermo, Italy.
出版信息
Scand J Gastroenterol. 1996 Apr;31(4):372-5. doi: 10.3109/00365529609006413.
BACKGROUND
No data on mortality for Crohn's disease are available from southern Europe.
METHODS
Five hundred and thirty-one patients with Crohn's disease were observed in our unit between 1973 and 1993. In 325 patients the first diagnosis was made in our hospital. In this consecutive incidence series, in which the follow-up was 99% complete, the standardized mortality rate (SMR) was calculated.
RESULTS
Nine deaths were observed, against 9.25 expected. The SMR was 0.97 (95% confidence interval (CI), 0.4-1.8). The relative risk of dying was significantly higher in the female group in the first 5 years after diagnosis (SMR, 10.3; 95% CI, 2.30-30.2). There was an excess of deaths from tumors of the digestive organs (1 observed, 0.37 expected).
CONCLUSIONS
These results show that in our geographic area the mortality from Crohn's disease was not increased as shown in other community studies.
背景
南欧尚无关于克罗恩病死亡率的数据。
方法
1973年至1993年间，我们科室观察了531例克罗恩病患者。其中325例患者在我院首次确诊。在这个连续性发病系列中，随访完成率为99%，计算了标准化死亡率（SMR）。
结果
观察到9例死亡，预期为9.25例。标准化死亡率为0.97（95%置信区间（CI），0.4 - 1.8）。诊断后的前5年，女性组的死亡相对风险显著更高（标准化死亡率，10.3；95%置信区间，2.30 - 30.2）。消化器官肿瘤导致的死亡人数超预期（观察到1例，预期为0.37例）。
结论
这些结果表明，在我们所在的地理区域，克罗恩病的死亡率并未如其他社区研究所示那样升高。
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