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细胞松弛素W,一种来自异形茎点霉的新型24-氧杂[14]细胞松弛素。

Cytochalasin W, a new 24-oxa[14]cytochalasan from Phoma exigua var. heteromorpha.

作者信息

Evidente A, Capasso R, Vurro M, Bottalico A

机构信息

Dipartimento di Scienze Chimico-Agrarie, Università di Napoli Federico II, Portici, Italy.

出版信息

Nat Toxins. 1996;4(2):53-7. doi: 10.1002/19960402nt1.

DOI:10.1002/19960402nt1
PMID:8726324
Abstract

A further cytochalasin was isolated from liquid culture filtrates of Phoma exigua var. heteromorpha together with cytochalasins U and V and other well-known cytochalasins. The metabolite, named cytochalasin W, was characterized by spectroscopic and chemical methods as a new 24-oxa[14]cytochalasan, bearing a formyl group on the macrocyclic ring. Cytochalasin W showed toxic activity in the brine shrimp assay.

摘要

从异形茎点霉液体培养滤液中分离出了另一种细胞松弛素,它与细胞松弛素U、V及其他知名细胞松弛素一同被分离出来。这种代谢产物被命名为细胞松弛素W,通过光谱和化学方法鉴定为一种新的24-氧杂[14]细胞松弛素,其大环上带有一个甲酰基。细胞松弛素W在卤虫检测中显示出毒性活性。

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