Gottschling L L, Alaniz C
Department of Pharmacy, William Beaumont Hospital, Royal Oak, Michigan, USA.
Pharmacotherapy. 1996 May-Jun;16(3):469-72.
Heparin is widely used in current practice for a variety of indications. It is well known that it can cause thrombocytopenia, but not that thrombosis may also develop in thrombocytopenic patients and cause significant morbidity and mortality. A 56-year-old woman developed heparin-induced thrombocytopenia with thrombosis that resulted in the amputation of her leg. It is proposed that the reaction has an immune-mediated mechanism. Several ways of diagnosing the condition are available, specifically the serotonin-release assay and an enzyme-linked immunosorbent assay. The investigational agent danaproid may be effective in the treatment of heparin-induced thrombocytopenia with thrombosis.
肝素在当前临床实践中因多种适应症而被广泛使用。众所周知，它可导致血小板减少，但血小板减少的患者也可能发生血栓形成，并引起严重的发病率和死亡率，这一点却鲜为人知。一名56岁女性发生了肝素诱导的血小板减少伴血栓形成，最终导致腿部截肢。有人提出这种反应具有免疫介导机制。有几种诊断该病症的方法，特别是血清素释放试验和酶联免疫吸附测定。研究药物达那肝素可能对治疗肝素诱导的血小板减少伴血栓形成有效。
