Lübbe J, Kormann A, Adams V, Hassam S, Grätz K W, Panizzon R G, Burg G
Department of Dermatology, University Hospital, Zurich, Switzerland.
Dermatology. 1996;192(3):217-21. doi: 10.1159/000246369.
Verrucous carcinoma is a slowly growing, well-differentiated neoplasm with a predilection for the oral cavity.
Data on the association of human papillomavirus (HPV) with oral verrucous carcinoma are very scarce. We searched for the presence of HPV in different stages of the tumour in a patient repeatedly treated by means of surgery, cryotherapy, radiotherapy and chemotherapy over a decade.
HPV DNA was detected in archival tumour tissue by nested PCR. HPV types were identified based on restriction fragment analysis.
HPV type 11 was found in 1 early-stage and HPV 16 in 2 late-stage biopsy specimens of the tumour.
Our findings provide further evidence for a role of HPV in oral verrucous carcinoma. The case history emphasizes the importance of a joint clinicopathological approach to this tumour.
疣状癌是一种生长缓慢、分化良好的肿瘤，好发于口腔。
关于人乳头瘤病毒（HPV）与口腔疣状癌关联的数据非常稀少。我们对一名在十年间反复接受手术、冷冻疗法、放射疗法和化疗的患者肿瘤不同阶段的HPV存在情况进行了研究。
通过巢式聚合酶链反应在存档的肿瘤组织中检测HPV DNA。基于限制性片段分析鉴定HPV类型。
在该肿瘤的1份早期活检标本中发现了11型HPV，在2份晚期活检标本中发现了16型HPV。
我们的研究结果为HPV在口腔疣状癌中的作用提供了进一步证据。该病例强调了对这种肿瘤采用联合临床病理方法的重要性。
