异常子宫内膜的流式细胞术DNA分析。

Flow cytometric DNA analysis of abnormal endometrium.

作者信息

Sato S, Tanoguchi K, Tase T, Yajima A

机构信息

Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Tohoku J Exp Med. 1996 Feb;178(2):199-202. doi: 10.1620/tjem.178.199.

DOI:10.1620/tjem.178.199

PMID:8727701

Abstract

Samples of abnormal endometrium, which were composed of 5 cases of atypical hyperplasia (ATH), 12 cases of well differentiated adenocarcinoma (G1), 17 cases of moderately differentiated adenocarcinoma (G2), 11 cases of poorly differentiated adenocarcinoma (G3) and 2 cases of serous papillary adenocarcinoma (SPA), were analyzed by flow cytometry. With respect to the ploidy level, all cases of both ATH and G1 showed diploidy, and the proliferative index (PI) was 14.32 and 16.33, respectively. In contrast, 3 of G2 cases, 3 of G3 cases and all of SPA cases showed aneuploid patterns, and the PI was 21.06, 27.91 and 31.52, respectively. There were statistical differences between the former group and the latter group as to both the ploidy and the PI. It was found that ATH and G1 had similar biological behavior.

摘要

对由5例不典型增生（ATH）、12例高分化腺癌（G1）、17例中分化腺癌（G2）、11例低分化腺癌（G3）和2例浆液性乳头状腺癌（SPA）组成的异常子宫内膜样本进行了流式细胞术分析。关于倍体水平，ATH和G1的所有病例均显示二倍体，增殖指数（PI）分别为14.32和16.33。相比之下，G2的3例、G3的3例以及所有SPA病例均显示非整倍体模式，PI分别为21.06、27.91和31.52。前一组和后一组在倍体和PI方面均存在统计学差异。发现ATH和G1具有相似的生物学行为。