Shelley W B, Hashim M, Shelley E D
Department of Medicine, Medical College of Ohio, Toledo 43699-0008, USA.
Cutis. 1996 Apr;57(4):232-4.
Twelve children ages 1 to 5 years and one adult with hand-foot-and-mouth disease were treated with oral acyclovir within one to two days of onset of the rash. Symptomatic relief, defervescence, and significant involution of lesions were seen within twenty-four hours of initiating therapy. Acyclovir was continued for five days, by which time palmar, plantar, and oral lesions were virtually gone. Acyclovir is a molecule tailored to inactivate the thymidine kinase of the herpesvirus. Since the Coxsackie A16 virus causing hand-foot-and-mouth disease lacks this enzyme, the beneficial therapeutic effect must be explained on other grounds, possibly due to enhancement of the antiviral effect of the patient's own interferon.
12名1至5岁的儿童和1名患有手足口病的成人在出疹后1至2天内接受了口服阿昔洛韦治疗。在开始治疗后的24小时内，症状得到缓解，发热消退，病变明显消退。阿昔洛韦持续服用5天，此时手掌、足底和口腔病变几乎消失。阿昔洛韦是一种专门用于使疱疹病毒的胸苷激酶失活的分子。由于引起手足口病的柯萨奇A16病毒缺乏这种酶，其有益的治疗效果必须从其他方面来解释，可能是由于增强了患者自身干扰素的抗病毒作用。
