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使用流体静压作为研究病毒和其他大分子聚集体的工具。

The use of hydrostatic pressure as a tool to study viruses and other macromolecular assemblages.

作者信息

Silva J L, Foguel D, Da Poian A T, Prevelige P E

机构信息

Departamento de Bioquimica Médica, Universidade Federal do Rio de Janeiro, Brazil.

出版信息

Curr Opin Struct Biol. 1996 Apr;6(2):166-75. doi: 10.1016/s0959-440x(96)80071-6.

DOI:10.1016/s0959-440x(96)80071-6
PMID:8728649
Abstract

Recent studies on the effect of pressure on macromolecular assemblages have provided new information on protein-protein and protein-nucleic acid interactions. New findings have recently emerged on the use of hydrostatic pressure to assess intermediate states in the assembly pathways of viruses, multimeric proteins and protein-nucleic acid complexes, addressing many questions of macromolecular recognition.

摘要

近期关于压力对大分子聚集体影响的研究,为蛋白质-蛋白质和蛋白质-核酸相互作用提供了新信息。最近出现了关于利用流体静压力评估病毒、多聚体蛋白和蛋白质-核酸复合物组装途径中的中间状态的新发现,解决了许多大分子识别问题。

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