不同种族起源家庭中斯耶格伦-拉松综合征与17号染色体连锁的确认。
Confirmation of linkage of Sjögren-Larsson syndrome to chromosome 17 in families of different ethnic origins.
作者信息
Lacour M, Middleton-Price H R, Harper J I
机构信息
Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.
出版信息
J Med Genet. 1996 Mar;33(3):258-9. doi: 10.1136/jmg.33.3.258.
Linkage analysis in two consanguineous pedigrees of Pakistani and English origin and one further Indian family in which affected subjects have Sjögren-Larsson syndrome (SLS) showed linkage to chromosome 17. Linkage of SLS to D17S783 and D17S805 has been reported in Swedish pedigrees, but since those data were generated from a single ethnic group originating from a common ancestor, there remained the question of whether this disease is genetically heterogeneous. This report confirms the linkage in non-Swedish pedigrees and, therefore, provides evidence to support a single locus for SLS.
对两个分别来自巴基斯坦和英国的近亲家系以及另一个印度家系进行连锁分析，这些家系中的患病个体患有舍格伦-拉松综合征（SLS），结果显示该综合征与17号染色体连锁。在瑞典家系中已报道SLS与D17S783和D17S805存在连锁关系，但由于这些数据来自于源自共同祖先的单一族群，因此仍存在该疾病是否存在基因异质性的问题。本报告证实了在非瑞典家系中的连锁关系，因此为支持SLS由单一基因座决定提供了证据。
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