The neurotoxicity of 5,7-dihydroxytryptamine in the mouse atrium: protection by 1-phenyl-3-(2-thiazolyl)-2-thiourea and by ethanol.

1-Phenyl-3-(2-thiazolyl)-2-thiourea (200 mg/kg, 1 h) protected the adrenergic nerve plexus in the mouse atrium against the destructive action of i.v. 5,7-dihydroxytryptamine. Protection was also observed with ethanol (4 g/kg, 1 h) and with nialamide (50 mg/kg, 2 h).