Vieira Botelho R, Feres F, São Thiago L E, Abud R, Carneiro J K, Pinto I, Rego Sousa A G, Rego Sousa J E
Instituto Dante Pazzanese de Cardiologia, São Paulo.
Arq Bras Cardiol. 1995 Oct;65(4):313-5.
To evaluate the vasodilation effect of intracoronary isosorbide mononitrate (ISMN) on the coronary arteries, systolic aortic pressure (SAP) and cardiac rhythms.
Forty patients aged 61 (40-72) years, 30 (75%) male, were randomized to receive on a double blind fashion, 20 mg of ISMN or placebo. The two groups had similar baseline characteristics. Quantitative coronary arteriography [by cardiovascular measurement system (CMS)] and SAP were compared before and after ISMN. We also observed the cardiac rhythm.
There were no arrhythmias. Reference vessel diameter increased from 2.6 +/- 0.5 mm before to 2.9 +/- 0.4 mm after ISMN and did not change, mean 2.9 +/- 0.5 mm, before and after placebo. There was a difference between ISMN and placebo (p < 0.0001). There was no difference in the SAP change between the two groups, 4.2 +/- 0.7 mmHg with ISMN and 1.8 +/- 0.5 mmHg with placebo (p = NS).
ISMN promotes a safe and effective vasodilation of the coronary arteries with no major effects in cardiac rhythm and systolic aortic pressure.
评估冠状动脉内单硝酸异山梨酯（ISMN）对冠状动脉、收缩期主动脉压（SAP）及心律的血管舒张作用。
40例年龄61（40 - 72）岁、30例（75%）为男性的患者，以双盲方式随机接受20 mg ISMN或安慰剂。两组基线特征相似。在给予ISMN前后，采用心血管测量系统（CMS）通过定量冠状动脉造影及SAP进行比较。我们还观察了心律。
未出现心律失常。参照血管直径在给予ISMN前为2.6±0.5 mm，之后为2.9±0.4 mm，给予安慰剂前后均值为2.9±0.5 mm，无变化。ISMN与安慰剂之间存在差异（p < 0.0001）。两组间SAP变化无差异，ISMN组为4.2±0.7 mmHg，安慰剂组为1.8±0.5 mmHg（p = 无统计学意义）。
ISMN可促进冠状动脉安全有效地血管舒张，对心律和收缩期主动脉压无重大影响。
