Sánchez Luceros A, Koziner B
Unidad de Trasplante de Médula Osea de Clínica Independencia, Hospital Privado de Oncología, Munro, Buenos Aires.
Medicina (B Aires). 1995;55(4):366-72.
The administration of high dose chemotherapy and or radiotherapy with autologous hematopoietic rescue has become a treatment modality with increasing number of indications in a variety of malignant conditions. Improvements in the conditioning regimens and supportive measures used, as well as a more refined patient selection based on prognostic factors, have resulted in progressively better results. The availability of precursor cells from peripheral blood has allowed a faster restoration of hematopoiesis, decreasing the period and intensity of myelosuppression. The following revision gives an updated image of the accumulated experience with this mode of support in malignant lymphomas.
大剂量化疗联合或不联合放疗并进行自体造血挽救,已成为一种在多种恶性疾病中适应证不断增加的治疗方式。所采用的预处理方案和支持措施的改进,以及基于预后因素进行的更精细的患者选择,都带来了越来越好的治疗效果。外周血中前体细胞的可获得性使得造血功能得以更快恢复,缩短了骨髓抑制的时间和强度。以下综述呈现了在恶性淋巴瘤中这种支持模式的累积经验的最新情况。