Labau E, Bonnet E, Alric L, Massip P
Service de Pathologie infectieuse, CHU Rangueil, Toulouse.
Presse Med. 1996 Feb 3;25(4):162-6.
Knowledge of the pathophysiological mechanisms governing Parvovirus B19 infection has been modified with the recent discovery of its cellular receptor. The cell lines susceptible to infection can be identified on the basis of the nature and distribution of the virus in the human organism. The Parvovirus B19 can undergo two types of cycles within the host cell. The first is a complete cycle within the infected cell leading to cell death by lysis. In the second, the cycle aborts and cell death is caused by an association of immunological phenomena and the accumulation of viral proteins toxic to the cell. It is not known why complete cycles are restricted to a single erythrocyte line. These new data not only give a more precise explanation of the classical clinical expression of the disease, but also suggest possible mechanisms for the pathogenic power of the Parvovirus B19, some of which have already been proposed on the basis of clinical observations.
随着细小病毒B19细胞受体的最新发现，对其感染所涉及的病理生理机制的认识已有所改变。可根据病毒在人体中的性质和分布来确定易受感染的细胞系。细小病毒B19可在宿主细胞内经历两种类型的循环。第一种是在受感染细胞内的完整循环，导致细胞通过裂解死亡。第二种情况是，循环中止，细胞死亡是由免疫现象和对细胞有毒的病毒蛋白积累共同作用引起的。目前尚不清楚为何完整循环仅限于单一红细胞系。这些新数据不仅对该疾病的经典临床表现给出了更精确的解释，还提示了细小病毒B19致病力的可能机制，其中一些机制已基于临床观察提出。
