[具有脂环族残基的利多氟嗪衍生物的冠状动脉扩张活性]
[Lidoflazine derivatives with cycloaliphatic residues of coronary dilator activity].
作者信息
Carissimi M, Gentili P, Picciòla G, Ravenna F
出版信息
Farmaco Sci. 1977 Jun;32(6):461-70.
PMID:872926
Abstract
The preparation of some derivatives of lidoflazine bearing a phenylcyclohexane residue in place of the m.xylene is described. Study of the coronary dilating activity on the isolated heart showed that this activity is markedly increased by the modification. Acute toxicity in rats is also strongly increased.
摘要
描述了一些用苯基环己烷残基取代间二甲苯的利多氟嗪衍生物的制备方法。对离体心脏冠状动脉扩张活性的研究表明，这种修饰显著增强了该活性。大鼠的急性毒性也大幅增加。
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