Leis D, Botterman P, Ermler R, Maurer U
Fertil Steril. 1977 Jul;28(7):737-40. doi: 10.1016/s0015-0282(16)42675-0.
Forty 3-hour oral glucose tolerance tests (OGTTs) were performed in 10 assumedly healthy female volunteers 19 to 30 years old, each serving four times as her own control. Each subject was taking a sequential type oral contraceptive containing either 50 microgram of ethinylestradiol or 80 microgram of mestranol alternatingly in four consecutive treatment cycles. The OGTTs were performed on the 6th day of each cycle, during pure estrogen medication. Blood glucose and serum insulin values did not differ significantly under either estrogen as tested by the t-test for paired observations. Our results do not support the findings of others that mestranol has a more pronounced or even exclusively adverse effect on glucose tolerance as compared with ethinylestradiol.
对10名年龄在19至30岁之间的假定健康女性志愿者进行了40次3小时口服葡萄糖耐量试验（OGTT），每名志愿者作为自身对照进行了4次试验。每位受试者在连续4个治疗周期中交替服用含有50微克炔雌醇或80微克炔诺酮的序贯式口服避孕药。OGTT在每个周期的第6天进行，处于单纯雌激素用药期间。通过配对观察的t检验，两种雌激素下的血糖和血清胰岛素值均无显著差异。我们的结果不支持其他人的研究结果，即与炔雌醇相比，炔诺酮对葡萄糖耐量有更明显甚至完全不利的影响。
