长期使用抗惊厥药物期间肝酶的水平。

Hepatic enzymes' level during chronic use of anticonvulsant drugs.

作者信息

Hoshino M, Heise C O, Puglia P, Almeida A B, Cukiert A

机构信息

Department of Neurology and Neurosurgery, University of São Paulo School of Medicine, Brazil.

出版信息

Arq Neuropsiquiatr. 1995 Dec;53(4):719-23. doi: 10.1590/s0004-282x1995000500001.

DOI:10.1590/s0004-282x1995000500001

PMID:8729762

Abstract

We studied retrospectively 894 adult epileptic patients treated during the period from 1983 to 1992. Hepatic enzymes abnormal values were seen in 49% (n = 438). In 22.3% (n = 200), at least 2 enzyme levels in different moments were altered. They were divided in three groups: GI with alterations at transaminases (3%, n = 6), GII with alterations at GGT and AP enzymes (72%, n = 144) and GIII with alterations in both groups (25%, n = 50). No patient developed clinical symptoms of liver disease. The increase of gamma-glutamil-transferase (GGT) and alkaline phosphatase (AP) levels is frequent and not necessarily pathological. Slight increase of transaminases can occur with no clinical correlation. The routine screening of hepatic enzymes level during the chronic use of anticonvulsivant drugs in adults has a questionable value.

摘要

我们回顾性研究了1983年至1992年期间接受治疗的894例成年癫痫患者。49%（n = 438）的患者出现肝酶异常值。22.3%（n = 200）的患者在不同时间至少有2种酶水平发生改变。他们被分为三组：GI组转氨酶改变（3%，n = 6），GII组γ-谷氨酰转移酶（GGT）和碱性磷酸酶（AP）改变（72%，n = 144），GIII组两组均改变（25%，n = 50）。没有患者出现肝病的临床症状。γ-谷氨酰转移酶（GGT）和碱性磷酸酶（AP）水平升高很常见，且不一定是病理性的。转氨酶轻度升高可能出现，但与临床无关。在成人长期使用抗惊厥药物期间常规筛查肝酶水平的价值存疑。