Buskila D, Lorber M, Neumann L, Flusser D, Shoenfeld Y
Rheumatic Disease Unit, Soroka Medical Center, Ben-Gurion University, Beer-Sheva, Israel.
J Rheumatol. 1996 Apr;23(4):629-32.
To assess the frequency of hyperprolactinemia and its possible clinical significance in patients with systemic lupus erythematosus (SLE).
Concentrations of prolactin (PRL) were determined in 63 consecutive patients with SLE by an immunoradiometric assay. Antinuclear antibodies, anti-DNA, ribonucleoprotein, Sm, Ro, La, and anticardiolipin antibodies were determined by standard techniques. PRL concentrations were correlated with SLE clinical and serological activity.
Elevated serum concentration of PRL (> 20 ng/ml) were found in 10 of 63 (15.9%) patients [21 to 57 ng/ml, mean (SD) 35.6 (13.4)]. No direct correlation between PRL levels and clinical disease activity of SLE was found (Pearson correlation r = -0.186, NS). In addition, hyperprolactinemia was not associated with serological activity.
Mild hyperprolactinemia is present in a subset of patients with SLE but its clinical significance is still uncertain.
评估系统性红斑狼疮（SLE）患者高催乳素血症的发生率及其可能的临床意义。
采用免疫放射分析法测定63例连续的SLE患者的催乳素（PRL）浓度。通过标准技术检测抗核抗体、抗DNA、核糖核蛋白、Sm、Ro、La和抗心磷脂抗体。PRL浓度与SLE的临床和血清学活动相关。
63例患者中有10例（15.9%）血清PRL浓度升高（>20 ng/ml）[21至57 ng/ml，平均（标准差）35.6（13.4）]。未发现PRL水平与SLE临床疾病活动之间存在直接相关性（Pearson相关系数r = -0.186，无统计学意义）。此外，高催乳素血症与血清学活动无关。
一部分SLE患者存在轻度高催乳素血症，但其临床意义仍不确定。
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