Leaños-Miranda A, Cárdenas-Mondragón G
Research Unit in Reproductive Medicine, Hospital de Ginecología y Obstetricia Luis Gastelazo Ayala, México city, México.
Rheumatology (Oxford). 2006 Jan;45(1):97-101. doi: 10.1093/rheumatology/kei115. Epub 2005 Oct 25.
To determine in patients with systemic lupus erythematosus (SLE) the relationships among serum total and free prolactin (PRL) levels, isoforms of PRL and lupus activity.
In a cross-sectional study, 259 patients with SLE were tested for serum total PRL, serum free PRL, and PRL in fractions obtained after gel filtration chromatography (in 70 sera taken at random) by immunoradiometric assay based on disease activity.
A significant correlation between direct PRL and free PRL levels was found in patients with and without lupus activity (r = 0.475, P<0.001); however, this was less so for non-active patients than for active patients (r=0.433, P<0.001 and r=0.909, P<0.001, respectively). SLE Disease Activity Index (SLEDAI) scores correlated positively with serum free PRL levels (r=0.314, P<0.001) and percentage of little PRL (r=0.33, P=0.005) and negatively with percentage of big big PRL (r=-0.3, P=0.012). Patients with active disease had higher serum free PRL levels (median 12.6 vs 9.3 ng/ml, P<0.001), higher percentages of little PRL (83.1 +/- 21.2 vs 63.6 +/- 24.8%, P=0.011) and lower percentages of big big PRL (9.4 +/- 18.0 vs 25.2 +/- 24.3%, P=0.031). Different clinical manifestations and serological parameters of lupus disease activity were more frequent in patients with free hyperprolactinaemia than in patients with normal serum free PRL levels (such as neurological manifestations, renal involvement, serositis, haematological manifestations, anti-double-stranded DNA and hypocomplementaemia; P<0.021).
An increase in serum free PRL levels, higher percentages of little PRL and lower percentages of big big PRL proved to be factors related to lupus activity in a subset of patients with SLE. These novel data must be taken into account in future studies aiming to establish a relationship between PRL and disease activity in SLE.
确定系统性红斑狼疮（SLE）患者血清总催乳素（PRL）和游离PRL水平、PRL亚型与狼疮活动度之间的关系。
在一项横断面研究中，对259例SLE患者进行检测，采用免疫放射分析法，根据疾病活动度检测血清总PRL、血清游离PRL以及凝胶过滤色谱分离后各组分中的PRL（随机选取70份血清）。
无论狼疮是否活动，直接PRL水平与游离PRL水平之间均存在显著相关性（r = 0.475，P<0.001）；然而，非活动患者的相关性低于活动患者（分别为r=0.433，P<0.001和r=0.909，P<0.001）。SLE疾病活动指数（SLEDAI）评分与血清游离PRL水平呈正相关（r=0.314，P<0.001），与小PRL百分比呈正相关（r=0.33，P=0.005），与大大PRL百分比呈负相关（r=-0.3，P=0.012）。活动期患者的血清游离PRL水平较高（中位数12.6对9.3 ng/ml，P<0.001），小PRL百分比更高（83.1±21.2对63.6±24.8%，P=0.011），大大PRL百分比更低（9.4±18.0对25.2±24.3%，P=0.031）。血清游离催乳素血症患者狼疮疾病活动的不同临床表现和血清学参数比血清游离PRL水平正常的患者更常见（如神经学表现、肾脏受累、浆膜炎、血液学表现、抗双链DNA和低补体血症；P<0.021）。
血清游离PRL水平升高、小PRL百分比升高和大大PRL百分比降低被证明是部分SLE患者狼疮活动的相关因素。在未来旨在建立PRL与SLE疾病活动度之间关系的研究中，必须考虑这些新数据。
