Herrick A L, Worthington H, Rieley F, Clarke D, Schofield D, Braganza J M, Jayson M I
University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK.
J Rheumatol. 1996 Apr;23(4):650-3.
To document habitual intakes of micronutrient antioxidants in patients with systemic sclerosis (SSc) in light of studies reporting subnormal levels of ascorbate and selenium in this patient group.
Dietary intakes of vitamin C, selenium, alpha-tocopherol, beta-carotene, and sulfur amino acid precursors of glutathione were assessed using the 7 day weighed record in 12 patients with SSc and in 12 healthy control subjects. The intakes of the first 4 substances were examined in relation to plasma/serum levels, while intakes of sulfur amino acids were examined in relation to urinary inorganic sulfate.
Antioxidant and sulfur amino acid intakes were similar in patients and controls, although the patients had lower levels of selenium (median 74 compared to 87 milligrams in controls; p = 0.014) and of vitamin C in plasma (median 6.0 compared to 11.1 milligrams/l in controls; p = 0.08). Inorganic sulfate concentration in urine was similar in patients and controls.
Our results suggest that reduced blood levels of the water soluble antioxidants selenium and ascorbic acid in patients with SSc are not due to dietary deficiency. Other explanations must therefore be sought.
鉴于有研究报道系统性硬化症（SSc）患者体内抗坏血酸和硒水平低于正常，记录该患者群体中微量营养素抗氧化剂的习惯性摄入量。
采用7天称重记录法，评估12例SSc患者和12例健康对照者膳食中维生素C、硒、α-生育酚、β-胡萝卜素以及谷胱甘肽的硫氨基酸前体的摄入量。检测前4种物质的摄入量与血浆/血清水平的关系，同时检测硫氨基酸摄入量与尿无机硫酸盐的关系。
患者和对照者的抗氧化剂和硫氨基酸摄入量相似，不过患者的硒水平较低（中位数为74，对照者为87毫克；p = 0.014），血浆中维生素C水平也较低（中位数为6.0，对照者为11.1毫克/升；p = 0.08）。患者和对照者尿中无机硫酸盐浓度相似。
我们的结果表明，SSc患者血液中水溶性抗氧化剂硒和抗坏血酸水平降低并非由于饮食缺乏。因此必须寻找其他解释。
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