Agnello V, Zhang Q X, Abel G, Knight G B
Lahey Hitchcock Medical Center, Burlington MA 01805, USA.
Clin Exp Rheumatol. 1995 Nov-Dec;13 Suppl 13:S101-4.
To determine the prevalence of monoclonal rheumatoid factors (mRF) bearing the WA cross-idiotype (WA XId) in hepatitis C virus (HCV) positive type II mixed cryoglobulins, to review recent studies on the role of HCV in the cutaneous vasculitis lesions in patients with type II cryoglobulinemia and to discuss the implication of these studies for the etiopathogenesis and therapy of the disease.
Thirty type II cryoglobulins were tested for WA and PO XId and for HCV RNA:
WA mRF were strongly, although not exclusively, associated with HCV in type II mixed cryoglobulinemia.
These and other recent studies from our laboratory suggest that chronic HCV infection may be the stimulus for the production of WA mRF and that HCV may be directly involved in the pathogenesis of the cutaneous vasculitis in patients with type II cryoglobulinemia. The association of HCV infection with the disease provides a rationale for anti-viral therapy and for monitoring therapy by measuring the HCV level in both blood and liver.
确定丙型肝炎病毒（HCV）阳性的II型混合冷球蛋白中携带WA交叉独特型（WA XId）的单克隆类风湿因子（mRF）的患病率，回顾近期关于HCV在II型冷球蛋白血症患者皮肤血管炎病变中作用的研究，并讨论这些研究对该疾病病因发病机制及治疗的意义。
对30份II型冷球蛋白进行WA和PO XId以及HCV RNA检测。
在II型混合冷球蛋白血症中，WA mRF与HCV密切相关，虽并非唯一相关。
我们实验室的这些研究及其他近期研究表明，慢性HCV感染可能是产生WA mRF的刺激因素，且HCV可能直接参与II型冷球蛋白血症患者皮肤血管炎的发病机制。HCV感染与该疾病的关联为抗病毒治疗以及通过检测血液和肝脏中的HCV水平来监测治疗提供了理论依据。
