Mascia M T, Vandelli L, Savazzi A M, Medici G, Ghini M, Zanni G, Lattuada I, Mussini C
Dipartimento Medicina Interna, Cattedra di Reumatologia, Università di Modena, Italy.
Clin Exp Rheumatol. 1995 Nov-Dec;13 Suppl 13:S153-5.
Striking evidence of HCV infection has been found in mixed cryoglobulinemia (MC) and HCV has been hypothesized to be the causative agent of this disease. To assess the association of C virus infection and cryoglobulinemia we studied cryoglobulin levels in 66 patients on maintenance hemodyalisis who were selected on the basis of HCVAb positivity and not because they were affected by liver disease. The control group was made up of 45 patients also on hemodyalisis but without HCV infection.
Circulating cryoglobulins were found in 34 (52%) of 66 HCV+ patients: the cryocrit was < 1% in 20, 1 to 5% in 12, and > 5% in 2 patients. The cryoglobulins were classified by immunofixation as type II in 8 and type III in 8 others; identification was not possible in 18 cases. In the HCVAb- control group untypable cryoglobulins were detected in 9% of the patients at < 1% by volume. No correlation was found between these data and the liver disease detected by biohumoral tests.
Our data confirm the close link between HCV infection and cryoglobulins; the prevalence of circulating cryoglobulins in uremic HCVAb+ patients is very close to that found in HCV-related liver disease.
在混合性冷球蛋白血症（MC）中发现了丙型肝炎病毒（HCV）感染的显著证据，并且有人提出HCV是这种疾病的病原体。为了评估丙型肝炎病毒感染与冷球蛋白血症之间的关联，我们研究了66例维持性血液透析患者的冷球蛋白水平，这些患者是根据HCV抗体阳性选择的，而不是因为他们患有肝脏疾病。对照组由45例同样接受血液透析但未感染HCV的患者组成。
66例HCV阳性患者中有34例（52%）检测到循环冷球蛋白：冷沉淀比容<1%的有20例，1%至5%的有12例，>5%的有2例。通过免疫固定法将冷球蛋白分类为II型的有8例，III型的有8例；18例无法鉴定。在HCV抗体阴性的对照组中，9%的患者检测到不可分型的冷球蛋白，体积<1%。这些数据与生物体液检测发现的肝脏疾病之间没有相关性。
我们的数据证实了HCV感染与冷球蛋白之间的密切联系；尿毒症HCV抗体阳性患者中循环冷球蛋白的患病率与HCV相关肝脏疾病中的患病率非常接近。
