Sastre M, Ventayol P, García-Sevilla J A
Department de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca (Balears), Spain.
Neuroreport. 1996 Jan 31;7(2):509-12. doi: 10.1097/00001756-199601310-00032.
The aim of this study was to quantitate imidazoline receptors in postmortem brains of heroin addicts who died of an opiate overdose. The density of I2-imidazoline receptors ([3H]idazoxan binding in the presence of adrenaline) and the immunoreactivity of the related 29/30 kDa imidazoline receptor protein were decreased (39% and 28%, respectively) in the frontal cortex. The density of brain I2-imidazoline receptors was also decreased in heroin-dependent rats (27%). This novel finding indicates that opiate addiction induces down-regulation of I2-imidazoline receptors in astrocytes, and presumably down-regulation of the functions associated with these receptors.
本研究的目的是对死于阿片类药物过量的海洛因成瘾者的死后大脑中的咪唑啉受体进行定量分析。在额叶皮质中，I2 - 咪唑啉受体的密度（在肾上腺素存在下的[3H]异咪唑烷结合）以及相关的29/30 kDa咪唑啉受体蛋白的免疫反应性均降低（分别降低了39%和28%）。海洛因依赖大鼠的大脑I2 - 咪唑啉受体密度也降低了（27%）。这一新发现表明，阿片类药物成瘾会导致星形胶质细胞中I2 - 咪唑啉受体下调，并且可能导致与这些受体相关的功能下调。
