Wang H, Wang X, Scheich H
Federal Institute for Neurobiology, Magdeburg, Germany.
Neuroreport. 1996 Jan 31;7(2):521-5. doi: 10.1097/00001756-199601310-00035.
Using a system capable of relatively localized and rapidrate transcranial magnetic stimulation (rTMS), evoked trains of complex spikes were studied in rodent auditory cortex. Low rate rTMS from 1 to 10Hz produced a frequency-dependent increase in spike rate. Iterations of rTMS resulted in long-term potentiation (LTP)-like, and more durable long-term depression (LTD)-like changes in evoked spike rate. These observations generate new perspectives for studying mechanisms of learning and memory non-invasively as well as introducing some caveats for use of rTMS in humans.
利用一种能够进行相对局部且快速率经颅磁刺激（rTMS）的系统，在啮齿动物听觉皮层中研究了诱发的复合锋电位序列。1至10Hz的低速率rTMS使锋电位发放率出现频率依赖性增加。rTMS的重复刺激导致诱发锋电位发放率出现类似长时程增强（LTP）以及更持久的类似长时程抑制（LTD）的变化。这些观察结果为无创研究学习和记忆机制带来了新的视角，同时也为rTMS在人类中的应用提出了一些注意事项。
