Cenni E, Ciapetti G, Cervellati M, Cavedagna D, Falsone G, Gamberini S, Pizzoferrato A
Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy.
J Biomed Mater Res. 1996 May;31(1):145-8. doi: 10.1002/(SICI)1097-4636(199605)31:1<145::AID-JBM16>3.0.CO;2-M.
The ability of some biomaterials to activate plasma coagulation system was examined in vitro. After contact of platelet-rich plasma with biomaterials, some markers of the thrombin formation, i.e., fragment 1 + 2 and fibrinopeptide A, and some inhibitors of the blood coagulation mechanism were tested. Fragment 1 + 2 and fibrinopeptide A were found to be increased by all of the materials, though to a different extent. In particular, fragment 1 + 2 and fibrinopeptide A were significantly increased upon contact with polybutylene terephthalate and with collagen coated polyethylene terephthalate, respectively. Also antithrombin III was shown to decrease following exposure to biomaterials, but statistical significance was found only for polyethylene terephthalate and polyvinylacetate. As a results of this wide range of variability in the parameters, it is advisable to explore the plasma coagulation system with a multiparametric approach in which thrombin formation and coagulation inhibitors are thoroughly investigated.
在体外检测了某些生物材料激活血浆凝血系统的能力。富含血小板的血浆与生物材料接触后，检测了凝血酶形成的一些标志物，即片段1 + 2和纤维蛋白肽A，以及一些血液凝固机制的抑制剂。发现所有材料均使片段1 + 2和纤维蛋白肽A增加，不过增加程度不同。特别是，与聚对苯二甲酸丁二醇酯和胶原包被的聚对苯二甲酸乙二酯接触后，片段1 + 2和纤维蛋白肽A分别显著增加。暴露于生物材料后抗凝血酶III也显示减少，但仅聚对苯二甲酸乙二酯和聚醋酸乙烯酯具有统计学意义。由于这些参数存在广泛的变异性，建议采用多参数方法探索血浆凝血系统，其中要对凝血酶形成和凝血抑制剂进行全面研究。
