Arnold S, Hubler M, Lott-Stolz G, Rüsch P
Department of Reproduction, Faculty of Veterinary Medicine, University of Zurich, Switzerland.
J Small Anim Pract. 1996 Apr;37(4):163-8. doi: 10.1111/j.1748-5827.1996.tb01951.x.
Thirty-two spayed bitches with urinary incontinence due to urethral sphincter incompetence, non-responsive to phenylpropanolamine administration, were treated by urethral submucosal injection of glutaraldehyde cross-linked collagen. Urinary incontinence resolved after a single injection in 19 of the bitches. Additional medication with phenylpropanolamine was necessary in five of these dogs, however. Of the 13 bitches that remained incontinent, the injections were repeated in nine. This resulted in a return to continence in five dogs, although two of these required additional medication for complete continence. The cure rate due to collagen injections alone is 53 per cent (17 of the 32 cases). A total of 41 injections were performed and no post-operative complications were observed.
32只因尿道括约肌功能不全导致尿失禁且对苯丙醇胺治疗无反应的绝育母犬，接受了尿道黏膜下注射戊二醛交联胶原治疗。19只母犬单次注射后尿失禁症状消失。然而，其中5只犬还需要额外使用苯丙醇胺药物。在剩下仍有尿失禁症状的13只母犬中，9只接受了重复注射。这使得5只犬恢复了控尿能力，不过其中2只犬为实现完全控尿还需要额外用药。仅通过胶原注射的治愈率为53%（32例中的17例）。总共进行了41次注射，未观察到术后并发症。
