Yam P S, Shelton G D, Simpson J W
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall.
J Small Anim Pract. 1996 Apr;37(4):179-83. doi: 10.1111/j.1748-5827.1996.tb01957.x.
Fifteen dogs with confirmed adult onset idiopathic megaoesophagus, in which no generalised muscle weakness was observed, were tested for the presence of acetylcholine receptor antibodies. Of these, six were found to have values greater than 0.6 nmol/litre, previously determined to be diagnostic of acquired myasthenia gravis. The mean serum titre value for these dogs was 5.59 nmol/litre (range 0.78 to 8.72 nmol/litre). It appears that a significant proportion of dogs presenting with megaoesophagus have myasthenia gravis and, if a prompt diagnosis and appropriate treatment can be instituted, clinical signs may improve.
对15只确诊为成年期特发性巨食管且未观察到全身性肌无力的犬进行了乙酰胆碱受体抗体检测。其中，6只犬的抗体值高于0.6 nmol/升，该数值此前被确定为获得性重症肌无力的诊断标准。这些犬的血清滴度平均值为5.59 nmol/升（范围为0.78至8.72 nmol/升）。似乎有相当比例出现巨食管的犬患有重症肌无力，若能迅速做出诊断并进行适当治疗，临床症状可能会改善。
