Strassman R J, Qualls C R, Berg L M
Department of Psychiatry, School of Medicine, University of New Mexico, Albuquerque, USA.
Biol Psychiatry. 1996 May 1;39(9):784-95. doi: 10.1016/0006-3223(95)00200-6.
Tolerance of the behavioral effects of the short-acting, endogenous hallucinogen, N,N-dimethyltryptamine (DMT) is seen inconsistently in animals, and has not been produced in humans. The nature and time course of responses to repetitive, closely spaced administrations of an hallucinogenic dose of DMT were characterized. Thirteen experienced hallucinogen users received intravenous 0.3 mg/kg DMT fumarate, or saline placebo, four times, at 30 min intervals, on 2 separate days, in a randomized, double-blind, design. Tolerance to "psychedelic" subjective effects did not occur according to either clinical interview or Hallucinogen Rating Scale scores. Adrenocorticotropic hormone (ACTH), prolactin, cortisol, and heart rate responses decreased with repeated DMT administration, although blood pressure did not. These data demonstrate the unique properties of DMT relative to other hallucinogens and underscore the differential regulation of the multiple processes mediating the effects of DMT.
短效内源性致幻剂N,N - 二甲基色胺（DMT）行为效应的耐受性在动物中表现不一，在人类中尚未产生。本研究对重复、间隔紧密给予致幻剂量DMT后的反应性质和时间进程进行了表征。13名有使用致幻剂经验的受试者参与了一项随机、双盲设计的研究，在两个不同的日子里，以30分钟的间隔静脉注射0.3mg/kg富马酸DMT或生理盐水安慰剂，各注射4次。根据临床访谈或致幻剂评分量表得分，对“迷幻”主观效应并未产生耐受性。重复给予DMT后，促肾上腺皮质激素（ACTH）、催乳素、皮质醇和心率反应均降低，尽管血压未降低。这些数据证明了DMT相对于其他致幻剂的独特性质，并强调了介导DMT效应的多个过程的差异调节。
