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[兔人工腱109HH腱化的超微结构观察]

[Ultrastructural observation of tendonization of artificial tendon 109HH in rabbit].

作者信息

Liu L, Cao Q, Xiao H

机构信息

Division of Electronic Microscope, First Military Medical College, Guangzhou.

出版信息

Zhonghua Wai Ke Za Zhi. 1995 Sep;33(9):523-5.

PMID:8731867
Abstract

Ten New Zealand rabbits were divided into 5 groups at random. Calcaneal tendons were cut bilaterally, then atificial tendon 109HH was used to connect the two ends of the cut tendon. Ultrastructural changes of control group and experimental groups at 2, 6, 12, 28 weeks after section were observed. The results showed that fibroblast proliferated and a lot of ribosome and RER appeared in plasm during 2 approximately 6 weeks, indicating artificial tendon caused fibroblast proliferation. During this period, fibroblast over synthesized collagenous protein and the synthesis of collagenous fibers peaked. During 12-28 weeks, the number of fibroblasts and the synthesis of collagenous protein decreased. Finally, fibroblasts became inactive tendon cells. With the formation of new tendons, the artificial tendens were degradated and absorbed, and disappeared after 12 weeks. The new tendon fibers became thicker and had the correct direction through reconstruction. The structure and function of new tendons could be restored to be consistent with normal values.

摘要

将10只新西兰兔随机分为5组。双侧切断跟腱,然后用109HH人工肌腱连接切断肌腱的两端。观察切断后2、6、12、28周对照组和实验组的超微结构变化。结果显示,在2至6周期间,成纤维细胞增殖,胞质内出现大量核糖体和粗面内质网,提示人工肌腱引起成纤维细胞增殖。在此期间,成纤维细胞过度合成胶原蛋白,胶原纤维合成达到峰值。在12至28周期间,成纤维细胞数量及胶原蛋白合成减少。最终,成纤维细胞转变为无活性的腱细胞。随着新肌腱的形成,人工肌腱逐渐降解吸收,12周后消失。新的肌腱纤维通过重塑变得更粗且方向正确。新肌腱的结构和功能可恢复至与正常值一致。

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