[丙二胺四乙酸的诱变效应]
[Mutagenic effects of bimolane].
作者信息
Chen S Q, Xue K X, Wu J Z, Ma G J
机构信息
Jiangsu Institute of Cancer Research, Nanjing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Nov;16(6):531-3.
AIM
To study the genotoxicity of bimolane.
METHODS
Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test.
RESULTS
Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (P < 0.01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150 micrograms/plate in Ames test.
CONCLUSION
Bimolane is a kind of genotoxic compound.
目的
研究丙二胺四乙酸的遗传毒性。
方法
将5、10和15mg·kg-1的丙二胺四乙酸腹腔注射到小鼠体内，以研究其对骨髓细胞染色体/染色单体畸变的影响。在艾姆斯试验中研究其对TA97、TA98、TA100、TA102的致突变作用。
结果
5、10和15mg·kg-1的丙二胺四乙酸诱导染色体/染色单体畸变，丙二胺四乙酸诱导的畸变细胞频率显著增加（P<0.01）；在艾姆斯试验中，不含S9的丙二胺四乙酸在100和150微克/平板的浓度下对TA98和TA102有诱变作用。
结论
丙二胺四乙酸是一种遗传毒性化合物。
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