Xiao S, Li D, Zhang D
Zhonghua Zhong Liu Za Zhi. 1996 Jan;18(1):30-3.
The study was conducted to compare the efficacy between a combined chemotherapy of ACNU (Nimustine hydrochloride, brand name Nidran), a new nitrosourea agent, and a combined chemotherapy of methyl-CCNU for advanced gastric cancer. One hundred and three cases of advanced gastric cancer were randomly allocated into Group A (Me-CCNU, 5-Fu and ADM) and Group B (ACNU, 5-Fu and ADM). The results showed that in Group A there was no CR or PR, while in Group B, although no CR, there were 8 PR (8/64 cases), denoting the response rate of 0% in Group A and 17.4% in Group B. The median survival period in Group A was 108 days and in Group B 112 days. Both groups well tolerated the treatment and there were no serious adverse effects. Quality of life (QOL) was better in Group B than in Group A. It is concluded that ACNU combination is superior to Me-CCNU combination for advanced gastric cancer.
本研究旨在比较新型亚硝基脲类药物ACNU（盐酸尼莫司汀，商品名尼氮芥）联合化疗与甲环亚硝脲联合化疗对晚期胃癌的疗效。103例晚期胃癌患者被随机分为A组（甲环亚硝脲、5-氟尿嘧啶和阿霉素）和B组（ACNU、5-氟尿嘧啶和阿霉素）。结果显示，A组无完全缓解（CR）或部分缓解（PR），而B组虽无CR，但有8例PR（8/64例），A组缓解率为0%，B组为17.4%。A组中位生存期为108天，B组为112天。两组对治疗耐受性良好，均未出现严重不良反应。B组生活质量（QOL）优于A组。结论是，ACNU联合化疗对晚期胃癌优于甲环亚硝脲联合化疗。
