Kinsella J P, Abman S H
Department of Pediatrics, Children's Hospital 80218-1088, USA.
J Perinatol. 1996 Mar-Apr;16(2 Pt 2 Su):S24-7.
Inhaled NO can cause marked improvement in oxygenation when optimal lung inflation is achieved and systemic blood volume and vascular resistance are adequate. However, inhaled NO alone is unlikely to cause sustained improvements in oxygenation in neonatal hypoxemic respiratory failure associated with severe parenchymal lung disease without extrapulmonary shunting. Inhaled NO may be an important tool in the management of severe PPHN when its application is limited to patients with severe extrapulmonary shunting.
当实现最佳肺膨胀且全身血容量和血管阻力适当时，吸入一氧化氮可使氧合显著改善。然而，对于伴有严重实质性肺部疾病且无肺外分流的新生儿低氧性呼吸衰竭，仅吸入一氧化氮不太可能使氧合持续改善。当吸入一氧化氮仅应用于患有严重肺外分流的患者时，它可能是治疗严重持续性肺动脉高压的重要工具。
