Weston P J, Robinson J E, Watt P A, Thurston H
Department of Medicine and Therapeutics, Leicester Royal Infirmary, UK.
J Hum Hypertens. 1996 Mar;10(3):163-6.
The aim of this study was to evaluate the reproducibility of the circadian blood pressure (BP) change in normal healthy volunteers. The subjects were 32 healthy, young, normotensive volunteers who underwent 24 h ambulatory BP monitoring on two occasions, at least 4 weeks apart. Data were analysed using standard definitions of day and night (i.e. 07.00-22.00 for daytime and 22.00-07.00 for night time), event diaries to identify individual's day and night time and a time independent method (cusum analysis). Intraindividual variations of BP were assessed using the coefficient of variation (CV). The mean 24 h BP was very reproducible with a CV of 4.7%. Using the fixed definition of day and night, mean night time systolic blood pressure (SBP) was significantly reduced on the second visit compared to the first (P < 0.001). Using fixed times for day and night, day-night difference was poorly reproducible, with a CV of 52% for SBP and 59% for diastolic blood pressure (DBP), however this improved using diary based day-night to 40/41% and cusum analysis to 24.6/28.1%. We recommend that circadian BP changes are studied using individual definitions of day and night or time independent methods such as cusum analysis.
本研究的目的是评估正常健康志愿者昼夜血压（BP）变化的可重复性。研究对象为32名健康、年轻的血压正常志愿者，他们接受了两次24小时动态血压监测，两次监测间隔至少4周。使用白天和夜间的标准定义（即白天为07:00 - 22:00，夜间为22:00 - 07:00）、事件日记来确定个体的白天和夜间时间以及一种与时间无关的方法（累积和分析）对数据进行分析。使用变异系数（CV）评估血压的个体内变异。24小时平均血压具有很高的可重复性，CV为4.7%。采用固定的昼夜定义，第二次就诊时夜间平均收缩压（SBP）与第一次相比显著降低（P < 0.001）。采用固定的昼夜时间，昼夜差异的可重复性较差，SBP的CV为52%，舒张压（DBP）的CV为59%，然而，使用基于日记的昼夜划分时，CV改善至40/41%，使用累积和分析时，CV改善至24.6/28.1%。我们建议使用个体的昼夜定义或累积和分析等与时间无关的方法来研究昼夜血压变化。
