Kangro T, Henriksen E, Jonason T, Nilsson H, Ringqvist I
Department of Clinical Physiology, Central Hospital, Västerås, Sweden.
Eur Heart J. 1996 Apr;17(4):612-8. doi: 10.1093/oxfordjournals.eurheartj.a014916.
Age is an important determinant of Doppler indices of left ventricular diastolic filling in normal subjects. To define reference values and factors of importance to Doppler indices of left ventricular filling in subjects of similar age, 58 men and 76 women aged 50 years underwent Doppler echocardiography. All those taking part in the study were healthy. When gender was analysed in a multivariate model it showed a significant independent correlation with the peak velocity of early diastolic filling (E wave) (P < 0.001) and the early to atrial peak velocity (E/A) ratio (P < 0.01). The peak E wave velocity was 0.75 +/- 0.11 m.s-1 vs 0.66 +/- 0.10 m.s-1 (P < 0.001) and the E/A ratio was 1.24 +/- 0.25 vs 1.14 +/- 0.20 (P < 0.05) in women and men, respectively. In multivariate analyses, heart rate, diastolic blood pressure and body mass index correlated independently with the E/A ratio in women (P < 0.001 for all), whereas in men, heart rate, diastolic blood pressure, body mass index and left ventricular diameter correlated independently with the E/A ratio (P < 0.001 for all). Doppler measurements of left ventricular filling in 50-year-old healthy subjects showed a wide variation and were significantly associated with heart rate, diastolic blood pressure, body mass index and gender.
年龄是正常受试者左心室舒张期充盈多普勒指数的重要决定因素。为了确定年龄相仿受试者左心室充盈多普勒指数的参考值及重要影响因素，对58名男性和76名50岁女性进行了多普勒超声心动图检查。所有参与研究的人均身体健康。在多变量模型中分析性别时发现，其与舒张早期充盈峰值速度（E波）（P<0.001）和舒张早期与心房峰值速度之比（E/A）（P<0.01）存在显著独立相关性。女性的E波峰值速度为0.75±0.11m·s⁻¹，男性为0.66±0.10m·s⁻¹（P<0.001）；女性的E/A比值为1.24±0.25，男性为1.14±0.20（P<0.05）。在多变量分析中，心率、舒张压和体重指数与女性的E/A比值独立相关（均P<0.001），而在男性中，心率、舒张压、体重指数和左心室直径与E/A比值独立相关（均P<0.001）。对50岁健康受试者左心室充盈的多普勒测量显示差异很大，且与心率、舒张压、体重指数和性别显著相关。
