Morrison-Stewart S L, Velikonja D, Corning W C, Williamson P
Department of Research, London Psychiatric Hospital, Ontario, Canada.
Psychol Med. 1996 May;26(3):605-12. doi: 10.1017/s0033291700035674.
Thirty schizophrenic patients (20 medicated, 10 off medication) were compared with 30 normal controls subjects matched for age, sex, handedness and intelligence. During the performance of a frontal activation task, normal subjects showed increased interhemispheric coherence between anterior brain regions. Schizophrenic patients did not show the same amount of bilateral anterior activation. During the performance of right hemisphere cognitive activation tasks, normal subjects and medicated schizophrenic patients showed significantly reduced bilateral interhemispheric coherence patterns, while the drug-free schizophrenic patients showed a trend towards this same pattern. It is suggested that these findings provide additional evidence for an aberrant functional organization of the brain in schizophrenia.
将30名精神分裂症患者（20名正在服药，10名未服药）与30名在年龄、性别、利手和智力方面相匹配的正常对照者进行比较。在执行额叶激活任务期间，正常受试者前脑区域之间的半球间连贯性增加。精神分裂症患者未表现出相同程度的双侧前部激活。在执行右半球认知激活任务期间，正常受试者和正在服药的精神分裂症患者表现出双侧半球间连贯性模式显著降低，而未服药的精神分裂症患者表现出朝着相同模式发展的趋势。这些发现为精神分裂症患者大脑功能组织异常提供了额外证据。
