Smith P, Esguep A
Departamento de Patología, Universidad de Chile, Santiago.
Rev Med Chil. 1995 Nov;123(11):1387-93.
A qualitative and quantitative histological analysis of minor salivary glands was carried out in 60 alcoholics and 20 matched control patients. Minor salivary glands biopsies were obtained and samples were processed for conventional light microscopy. A quantitative morphometrical assessment was carried out by counting the number of acinar cells present in an area by means of a squared grid eye piece. Neither hipertrophic nor atrophic responses were found in the quantitative analysis. Histological changes such as acinar degeneration, hyperemia, mononuclear inflammatory and fat infiltration were found in both experimental and control samples. None of these findings reached statistical significance. Eleven adult alcoholics without liver damage (ASD) presented duct dilatation. On the other hand, only 3 adult alcoholics with liver damage (ACD) developed this response. This difference was statistically significant (p = 0.02). Perhaps no difference was found when we compared ASD group with its respective control group (p = 0.699). We could not differentiate if this change was due to alcoholism or another undeterminated factor. At least under the scope of this study, we may conclude that minor salivary glands are scarcely affected by alcoholism even when liver damage has been established.
对60名酗酒者和20名配对的对照患者的小唾液腺进行了定性和定量组织学分析。获取小唾液腺活检组织并对样本进行常规光学显微镜处理。通过使用方格目镜计数某一区域内腺泡细胞的数量进行定量形态学评估。定量分析中未发现肥大或萎缩反应。在实验样本和对照样本中均发现了腺泡变性、充血、单核细胞炎症和脂肪浸润等组织学变化。这些发现均未达到统计学显著性。11名无肝损伤的成年酗酒者（ASD）出现导管扩张。另一方面，只有3名有肝损伤的成年酗酒者（ACD）出现了这种反应。这种差异具有统计学显著性（p = 0.02）。当我们将ASD组与其各自的对照组进行比较时，可能未发现差异（p = 0.699）。我们无法区分这种变化是由于酗酒还是其他未确定的因素所致。至少在本研究范围内，我们可以得出结论，即使已经出现肝损伤，小唾液腺也很少受到酗酒的影响。
