丹麦未经过筛选的人群中IgE介导的超敏反应与细胞介导的超敏反应之间的关系：丹麦格罗斯楚普过敏研究

The relationship between IgE-mediated and cell-mediated hypersensitivities in an unselected Danish population: the Glostrup Allergy Study, Denmark.

作者信息

Nielsen N H, Menné T

机构信息

Medical Department C, Glostrup Hospital, Denmark.

出版信息

Br J Dermatol. 1996 Apr;134(4):669-72. doi: 10.1111/j.1365-2133.1996.tb06967.x.

DOI:10.1111/j.1365-2133.1996.tb06967.x

PMID:8733368

Abstract

In this study, we have assessed the relationship between IgE-mediated and cell-mediated hypersensitivities in an unselected population living in western Copenhagen, Denmark. A total of 793 subjects, aged 15-69 years, were studied. Measurements of total serum IgE, prick tests with aero-allergens and patch tests with environmental haptens were performed in 561 (70.7% of 793) subjects. One or more positive prick tests were present in 28.4%, and contact sensitization occurred in 15.2%. When adjusted for the effects of sex and age, the probability of contact sensitization to one or more hapten was independent of serum IgE level (the odds ratio value (OR) = 1.0; 95% confidence interval (CI) = 0.7-1.4), and the probability of contact sensitization was independent of the number of positive prick tests (OR = 1.0; CI = 0.8-1.2). Contact sensitization appeared to be independent of enhanced IgE responsiveness in an unselected adult population.

摘要

在本研究中，我们评估了丹麦哥本哈根西部未经过挑选的人群中，IgE介导的超敏反应与细胞介导的超敏反应之间的关系。共研究了793名年龄在15至69岁之间的受试者。对其中561名（占793名的70.7%）受试者进行了血清总IgE测量、气源性变应原点刺试验以及环境半抗原斑贴试验。28.4%的受试者有一项或多项阳性点刺试验结果，15.2%的受试者发生了接触性致敏。在对性别和年龄的影响进行校正后，对一种或多种半抗原发生接触性致敏的概率与血清IgE水平无关（优势比（OR）值 = 1.0；95%置信区间（CI） = 0.7 - 1.4），且接触性致敏的概率与阳性点刺试验的数量无关（OR = 1.0；CI = 0.8 - 1.2）。在未经过挑选的成年人群中，接触性致敏似乎与增强的IgE反应性无关。