Edmonds D T
Clarendon Laboratory, Oxford, U.K.
J Theor Biol. 1996 Mar 7;179(1):55-60. doi: 10.1006/jtbi.1996.0048.
Current models for the action of linear biological motors may be grouped in two main categories. The conventional "bind and bend" models rely for their power stroke upon a structural change in the myosin headgroup (S1 fragment) which follows the binding of myosin to the F-actin filament. The more recent ratchet models demonstrate that directional motion of a particle along an asymmetrical ratchet is possible with a symmetrical but time-correlated stochastic drive. In this paper a new type of model is introduced which is deterministic like the "bind and bend" model but it requires no molecular structural changes to power the stroke. Like the ratchet models the motor is driven along the linear stator by tangential forces at the interface but the forces are electrostatic and controlled by the hydrolysis of ATP to ADP.
目前关于线性生物马达作用的模型主要可分为两大类。传统的“结合与弯曲”模型的动力冲程依赖于肌球蛋白头部基团（S1片段）的结构变化，这种变化发生在肌球蛋白与F-肌动蛋白丝结合之后。最近的棘轮模型表明，在对称但与时间相关的随机驱动下，粒子沿着不对称棘轮的定向运动是可能的。在本文中，引入了一种新型模型，它像“结合与弯曲”模型一样是确定性的，但它不需要分子结构变化来驱动冲程。与棘轮模型一样，马达通过界面处的切向力沿着线性定子驱动，但这些力是静电的，并由ATP水解为ADP来控制。
