Tuzuner N, Doğusoy G, Demirkesen C, Ozkan F, Altas K
Department of Pathology and Microbiology, University of Istanbul, Turkey.
J Laryngol Otol. 1996 Apr;110(4):348-52. doi: 10.1017/s0022215100133596.
Toxoplasmic lymphadenitis generally involves a solitary lymph node in the head and neck regions, without systemic symptoms. In order to determine the frequency of toxoplasmic lymphadenitis, we reviewed the histological sections of 731 consecutive patients with reactive lymph node hyperplasia. Amongst 731 patients, 112 had histological features supporting a diagnosis of toxoplasmic lymphadenitis (15.3 per cent). In 80 of these patients (71 per cent), either Indirect Haemaglutination test (IHA), in 37 cases, or the Enzyme-Linked Immunosorbent Assay (ELISA) for detecting toxoplasmic IgG or IgM antibodies, in 43 cases, were performed. In 76 out of 80 patients (95 per cent), histological features correlated well with serological studies. The IHA test was positive in 30 patients with a titre of 1/64 or higher. The IgG-ELISA test was positive in 11 whereas the IgM-ELISA test was positive in 28 patients. These results provide further evidence of the distinctive nature of the histological changes in toxoplasmic lymphadenitis, which should enable the clinician to make a confident diagnosis of acute acquired toxoplasmosis.
弓形虫性淋巴结炎通常累及头颈部的单个淋巴结，无全身症状。为了确定弓形虫性淋巴结炎的发生率，我们回顾了731例连续性反应性淋巴结增生患者的组织学切片。在731例患者中，112例具有支持弓形虫性淋巴结炎诊断的组织学特征（15.3%）。其中80例患者（71%）进行了检测，37例行间接血凝试验（IHA），43例行酶联免疫吸附测定（ELISA）以检测弓形虫IgG或IgM抗体。80例患者中的76例（95%），其组织学特征与血清学研究结果相关性良好。IHA试验在30例患者中呈阳性，滴度为1/64或更高。IgG-ELISA试验在11例患者中呈阳性，而IgM-ELISA试验在28例患者中呈阳性。这些结果进一步证明了弓形虫性淋巴结炎组织学改变的独特性质，这应能使临床医生对急性获得性弓形虫病做出可靠诊断。
