Peckham D G, Spiteri M A
Department of Respiratory Medicine, North Staffordshire Hospital Trust, Stoke on Trent, UK.
Postgrad Med J. 1996 Apr;72(846):196-200. doi: 10.1136/pgmj.72.846.196.
Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology. The condition commonly affects young adults and frequently presents with bilateral hilar lymphadenopathy with or without pulmonary infiltration, ocular or cutaneous lesions. The clinical presentation can be extremely varied depending upon the organs affected. The diagnosis is firmly established when recognised clinical and radiographic findings are supported by histological evidence of discrete non-necrotising epithelioid cell granulomata in one or more organs. Sarcoidosis is usually self-limiting with spontaneous resolution, although in a few patients there is a progressive downhill course, culminating in irreversible fibrosis and severe impairment of organ function.
结节病是一种病因不明的多系统肉芽肿性疾病。该病常见于年轻人，常表现为双侧肺门淋巴结肿大，可伴有或不伴有肺部浸润、眼部或皮肤病变。临床表现因受累器官的不同而极为多样。当一个或多个器官中离散的非坏死性上皮样细胞肉芽肿的组织学证据支持已确认的临床和影像学表现时，即可明确诊断。结节病通常是自限性的，可自发缓解，尽管少数患者病情呈进行性恶化，最终导致不可逆的纤维化和器官功能严重受损。
