Strömberg I, Bickford P
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Neuroreport. 1996 Feb 29;7(3):693-6. doi: 10.1097/00001756-199602290-00003.
Long-term survival of fetal ventral mesencephalic grafts implanted into dopamine-depleted rats was studied. There was a reduction in apomorphine-induced rotations, which reached a maximum 3 months post-grafting. Striatal neuronal discharge rate was increased on the intact side of the aged grafted animals when compared with young adult striatum. Ipsilateral to the lesion, proximal to the graft, where the dopamine nerve terminal density was high but still much lower than that seen on the intact side, the firing rate was significantly lower than that measured in the intact side of the aged host. In conclusion, the increased firing rate seen in striatum after dopamine depletion is normalized by ventral mesencephalic grafts and does not show the age-related increase seen in 2-year-old rats.
对植入多巴胺耗尽大鼠体内的胎儿腹侧中脑移植物的长期存活情况进行了研究。阿扑吗啡诱导的旋转减少，在移植后3个月达到最大程度。与年轻成年纹状体相比，老年移植动物完整侧的纹状体神经元放电率增加。在损伤同侧、移植物近端，多巴胺神经末梢密度较高，但仍远低于完整侧，其放电率显著低于老年宿主完整侧的测量值。总之，多巴胺耗竭后纹状体中出现的放电率增加通过腹侧中脑移植物恢复正常，且未表现出2岁大鼠中出现的与年龄相关的增加。
