Sperber L T
Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, New York, New York, USA.
J Cataract Refract Surg. 1996 May;22(4):485-9. doi: 10.1016/s0886-3350(96)80047-2.
To assess the safety of neodymium:YAG (Nd:YAG) laser lens ablation in a rabbit model prior to human investigation.
The Nd:YAG laser lens ablation probe was inserted into the anterior chamber of 14 New Zealand white rabbit eyes and Nd:YAG laser lens ablation was simulated, exposing the eyes to energy significantly higher than that used in previous experimental Nd:YAG lens ablation of the human crystalline lens. After the procedure, the rabbits were killed at 1 hour, 1 day, or 1 week and the eyes evaluated by specular microscopy, ultrasonic pachymetry, and light microscopy.
There was no statistically significant difference in the postoperative endothelial cell counts or ultrasonic pachymetry of study eyes and control (unoperated) eyes. Light microscopy revealed no apparent damage to the cornea, trabecular meshwork, or retina of the study eyes.
the Nd:YAG laser lens ablation device appears to be a safe method of cataract removal in this animal model. Further study is needed to determine the safety and efficacy of this device for cataract removal in humans.
在人体研究之前，评估钕钇铝石榴石（Nd:YAG）激光晶状体消融术在兔模型中的安全性。
将Nd:YAG激光晶状体消融探头插入14只新西兰白兔眼的前房，模拟Nd:YAG激光晶状体消融，使眼睛暴露于比先前人类晶状体Nd:YAG激光消融实验中所用能量高得多的能量下。术后，在1小时、1天或1周处死兔子，通过镜面显微镜检查、超声测厚法和光学显微镜对眼睛进行评估。
研究眼与对照（未手术）眼的术后内皮细胞计数或超声测厚结果无统计学显著差异。光学显微镜检查显示，研究眼的角膜、小梁网或视网膜无明显损伤。
在该动物模型中，Nd:YAG激光晶状体消融装置似乎是一种安全的白内障摘除方法。需要进一步研究以确定该装置用于人类白内障摘除的安全性和有效性。
