慢性乙醇给药后大鼠脑海亚细胞组分的神经节苷脂长链碱基组成
Ganglioside long-chain base composition of rat brain subcellular fractions after chronic ethanol administration.
作者信息
Omodeo-Salé F, Gornati R, Palestini P
机构信息
Institute of General Physiology and Biochemistry, Faculty of Pharmacy, University of Milan, Italy.
出版信息
Alcohol. 1996 May-Jun;13(3):291-5. doi: 10.1016/0741-8329(95)02059-4.
Rats of two different ages (2 and 7 months) were treated with an ethanol-containing liquid diet for 24 days and change of the ceramide composition of gangliosides were studied in the brain synaptosomal, microsomal and myelin fractions. Greater differences were observed in the younger age, where ethanol treatment caused a significant increase of C20:1 LCB in GM1 ganglioside of synaptosomes and microsomes and in GD1a of myelin.
用含乙醇的液体饲料对两种不同年龄（2个月和7个月）的大鼠进行24天的处理，并研究了脑突触体、微粒体和髓磷脂部分神经节苷脂神经酰胺组成的变化。在较年轻的大鼠中观察到更大的差异，乙醇处理导致突触体和微粒体GM1神经节苷脂以及髓磷脂GD1a中C20:1长链碱基显著增加。
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