Emre S, Sungur A, Bilgiç S, Büyükpamukçu M, Günalp I, Ozgüç M
Department of Medical Biology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Pediatr Hematol Oncol. 1996 May-Jun;13(3):253-6. doi: 10.3109/08880019609030824.
Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumors. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.
