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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wu H X, Evreux-Gros C, Descotes J

Lyons Poisons Center, INSERM U80, Alexis Carrel Faculty of Medicine, France.

Hum Exp Toxicol. 1996 May;15(5):391-5. doi: 10.1177/096032719601500505.

The influence of cimetidine on diazinon toxicity and toxicokinetics was investigated in male Wistar rats. 2. The acute toxicity of diazinon, as well as brain acetylcholinesterase and carboxylesterase inhibition, were potentiated by pretreating rats with cimetidine (80 mg kg-1, i.p.) 1 and 24 h prior to diazinon application (50 mg kg-1, i.p.). 3. Comparison of toxicokinetic parameters between control and cimetidine-treated animals, showed a significant decrease in diazinon total body clearance and a marked increase in the area under the plasma concentration-time curve following cimetidine. 4. These results indicate that a major cause of the potentiation of diazinon may be related to the increase in the amount of diazinon in the systemic circulation as well as in the brain.

在雄性Wistar大鼠中研究了西咪替丁对二嗪农毒性和毒代动力学的影响。2. 在给予二嗪农（腹腔注射50 mg kg-1）前1小时和24小时，用西咪替丁（腹腔注射80 mg kg-1）预处理大鼠，可增强二嗪农的急性毒性以及对脑乙酰胆碱酯酶和羧酸酯酶的抑制作用。3. 对照动物与西咪替丁处理动物毒代动力学参数的比较显示，西咪替丁处理后二嗪农的全身清除率显著降低，血浆浓度-时间曲线下面积显著增加。4. 这些结果表明，二嗪农毒性增强的一个主要原因可能与全身循环以及脑中的二嗪农含量增加有关。

Wu H X, Evreux-Gros C, Descotes J

Lyons Poisons Center, INSERM U80, Alexis Carrel Faculty of Medicine, France.

Hum Exp Toxicol. 1996 May;15(5):391-5. doi: 10.1177/096032719601500505.

The influence of cimetidine on diazinon toxicity and toxicokinetics was investigated in male Wistar rats. 2. The acute toxicity of diazinon, as well as brain acetylcholinesterase and carboxylesterase inhibition, were potentiated by pretreating rats with cimetidine (80 mg kg-1, i.p.) 1 and 24 h prior to diazinon application (50 mg kg-1, i.p.). 3. Comparison of toxicokinetic parameters between control and cimetidine-treated animals, showed a significant decrease in diazinon total body clearance and a marked increase in the area under the plasma concentration-time curve following cimetidine. 4. These results indicate that a major cause of the potentiation of diazinon may be related to the increase in the amount of diazinon in the systemic circulation as well as in the brain.

在雄性Wistar大鼠中研究了西咪替丁对二嗪农毒性和毒代动力学的影响。2. 在给予二嗪农（腹腔注射50 mg kg-1）前1小时和24小时，用西咪替丁（腹腔注射80 mg kg-1）预处理大鼠，可增强二嗪农的急性毒性以及对脑乙酰胆碱酯酶和羧酸酯酶的抑制作用。3. 对照动物与西咪替丁处理动物毒代动力学参数的比较显示，西咪替丁处理后二嗪农的全身清除率显著降低，血浆浓度-时间曲线下面积显著增加。4. 这些结果表明，二嗪农毒性增强的一个主要原因可能与全身循环以及脑中的二嗪农含量增加有关。